Inglese, Christopher : rechercher sur Z-Library

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1

Immune-Mediated Diseases of the Central Nervous System

Co, Dominic O., Bordini, Brett J., Meyers, Arthur B., Inglese, Christopher

Journal:

Pediatric Clinics of North America

Année:

2017

Langue:

english

Fichier:

PDF, 1.63 MB

english, 2017

2

A Basis for Reduced Chemical Library Inhibition of Firefly Luciferase Obtained from Directed Evolution

Auld, Douglas S., Zhang, Ya-Qin, Southall, Noel T., Rai, Ganesha, Landsman, Marc, MacLure, Jennifer, Langevin, Daniel, Thomas, Craig J., Austin, Christopher P., Inglese, James

Journal:

Journal of Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 386 KB

english, 2009

3

A Dual-Fluorescence High-Throughput Cell Line System for Probing Multidrug Resistance

Brimacombe, Kyle R., Hall, Matthew D., Auld, Douglas S., Inglese, James, Austin, Christopher P., Gottesman, Michael M., Fung, King-Leung

Journal:

Assay and Drug Development Technologies

Année:

2009

Langue:

english

Fichier:

PDF, 35.37 MB

english, 2009

4

ChemInform Abstract: Synthesis and Evaluation of Quinazolin-4-ones as Hypoxia-Inducible Factor-1α Inhibitors.

Wenwei Huang, Ruili Huang, Matias S. Attene-Ramos, Srilatha Sakamuru, Erika E. Englund, James Inglese, Christopher P. Austin, Menghang Xia

Journal:

Année:

2012

Fichier:

PDF, 22 KB

2012

5

Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT–phosphoprotein interaction

Anton Simeonov, Adam Yasgar, Ajit Jadhav, G.L. Lokesh, Carleen Klumpp, Sam Michael, Christopher P. Austin, Amarnath Natarajan, James Inglese

Journal:

Analytical Biochemistry

Année:

2008

Langue:

english

Fichier:

PDF, 542 KB

english, 2008

6

A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression

Ronald L. Johnson, Wenwei Huang, Ajit Jadhav, Christopher P. Austin, James Inglese, Elisabeth D. Martinez

Journal:

Analytical Biochemistry

Année:

2008

Langue:

english

Fichier:

PDF, 495 KB

english, 2008

7

Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death

Ping Jun Zhu, John P. Hobson, Noel Southall, Cunping Qiu, Craig J. Thomas, Jiamo Lu, James Inglese, Wei Zheng, Stephen H. Leppla, Thomas H. Bugge, Christopher P. Austin, Shihui Liu

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 913 KB

english, 2009

8

Imidazolylpyrimidine based CXCR2 chemokine receptor antagonists

Koc-Kan Ho, Douglas S. Auld, Adolph C. Bohnstedt, Paolo Conti, Wim Dokter, Shawn Erickson, Daming Feng, Jim Inglese, Celia Kingsbury, Steven G. Kultgen, Rong-Qiang Liu, Christopher M. Masterson, Micha

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 131 KB

english, 2006

9

N4-Phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease

Wenwei Huang, Wei Zheng, Daniel J. Urban, James Inglese, Ellen Sidransky, Christopher P. Austin, Craig J. Thomas

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 187 KB

english, 2007

10

Identification of a potent new chemotype for the selective inhibition of PDE4

Amanda P. Skoumbourdis, Ruili Huang, Noel Southall, William Leister, Vicky Guo, Ming-Hsuang Cho, James Inglese, Marshall Nirenberg, Christopher P. Austin, Menghang Xia, Craig J. Thomas

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 421 KB

english, 2008

11

Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors

Amanda P. Skoumbourdis, Christopher A. LeClair, Eduard Stefan, Adrian G. Turjanski, William Maguire, Steven A. Titus, Ruili Huang, Douglas S. Auld, James Inglese, Christopher P. Austin, Stephen W. Mic

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 578 KB

english, 2009

12

Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk)

Bryan T. Mott, Cordelle Tanega, Min Shen, David J. Maloney, Paul Shinn, William Leister, Juan J. Marugan, James Inglese, Christopher P. Austin, Tom Misteli, Douglas S. Auld, Craig J. Thomas

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 715 KB

english, 2009

13

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

Jian-kang Jiang, Matthew B. Boxer, Matthew G. Vander Heiden, Min Shen, Amanda P. Skoumbourdis, Noel Southall, Henrike Veith, William Leister, Christopher P. Austin, Hee Won Park, James Inglese, Lewis

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 855 KB

english, 2010

14

Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries

Veith, Henrike, Southall, Noel, Huang, Ruili, James, Tim, Fayne, Darren, Artemenko, Natalia, Shen, Min, Inglese, James, Austin, Christopher P, Lloyd, David G

Journal:

Nature Biotechnology

Année:

2009

Langue:

english

Fichier:

PDF, 588 KB

english, 2009

15

High-throughput screening assays for the identification of chemical probes

Inglese, James, Johnson, Ronald L, Simeonov, Anton, Xia, Menghang, Zheng, Wei, Austin, Christopher P, Auld, Douglas S

Journal:

Nature Chemical Biology

Année:

2007

Langue:

english

Fichier:

PDF, 2.38 MB

english, 2007

16

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum

Yuan, Jing, Johnson, Ronald L, Huang, Ruili, Wichterman, Jennifer, Jiang, Hongying, Hayton, Karen, Fidock, David A, Wellems, Thomas E, Inglese, James, Austin, Christopher P

Journal:

Nature Chemical Biology

Année:

2009

Langue:

english

Fichier:

PDF, 632 KB

english, 2009

17

Identification of oxadiazoles as new drug leads for the control of schistosomiasis

Sayed, Ahmed A, Simeonov, Anton, Thomas, Craig J, Inglese, James, Austin, Christopher P, Williams, David L

Journal:

Nature Medicine

Année:

2008

Langue:

english

Fichier:

PDF, 302 KB

english, 2008

18

Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors

Wenwei Huang, Ruili Huang, Matias S. Attene-Ramos, Srilatha Sakamuru, Erika E. Englund, James Inglese, Christopher P. Austin, Menghang Xia

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 1.06 MB

english, 2011

19

Differentiating Alzheimer disease-associated aggregates with small molecules

Nicolette S. Honson, Ronald L. Johnson, Wenwei Huang, James Inglese, Christopher P. Austin, Jeff Kuret

Journal:

Neurobiology of Disease

Année:

2007

Langue:

english

Fichier:

PDF, 597 KB

english, 2007

20

Characterization of Diversity in Toxicity Mechanism Using in Vitro Cytotoxicity Assays in Quantitative High Throughput Screening

Huang, Ruili, Southall, Noel, Cho, Ming-Hsuang, Xia, Menghang, Inglese, James, Austin, Christopher P.

Journal:

Chemical Research in Toxicology

Année:

2008

Langue:

english

Fichier:

PDF, 1.58 MB

english, 2008

21

Characterization of Chemical Libraries for Luciferase Inhibitory Activity

Auld, Douglas S., Southall, Noel T., Jadhav, Ajit, Johnson, Ronald L., Diller, David J., Simeonov, Anton, Austin, Christopher P., Inglese, James

Journal:

Journal of Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 548 KB

english, 2008

22

Serum carnitine concentrations and felbamate therapy in children

Barry E. Gidal, Abel W. Eng, Gail D. Anderson, Christopher M. Inglese

Journal:

Journal of Epilepsy

Année:

1996

Langue:

english

Fichier:

PDF, 115 KB

english, 1996

23

A bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker

Ming-Hsuang Cho, Andrew Niles, Ruili Huang, James Inglese, Christopher P. Austin, Terry Riss, Menghang Xia

Journal:

Toxicology in Vitro

Année:

2008

Langue:

english

Fichier:

PDF, 808 KB

english, 2008

24

Dysfunction of executive and related processes in childhood absence epilepsy

Lisa L. Conant, Angus Wilfong, Christopher Inglese, Andrea Schwarte

Journal:

Epilepsy & Behavior

Année:

2010

Langue:

english

Fichier:

PDF, 255 KB

english, 2010

25

Diet- and valproate-induced transient hyperammonemia: effect of l-carnitine

Barry E. Gidal, Christopher M. Inglese, Jane F. Meyer, Michael E. Pitterle, Joann Antonopolous, Robert S. Rust

Journal:

Pediatric Neurology

Année:

1997

Langue:

english

Fichier:

PDF, 946 KB

english, 1997

26

Targeting the deep lungs, Poloxamer 407 and a CpG oligonucleotide optimize immune responses to Mycobacterium tuberculosis antigen 85A following pulmonary delivery

Todoroff, Julie, Ucakar, Bernard, Inglese, Malory, Vandermarliere, Sophie, Fillee, Catherine, Renauld, Jean-Christophe, Huygen, Kris, Vanbever, Rita

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Année:

2013

Langue:

english

Fichier:

PDF, 590 KB

english, 2013

27

Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors

Huh, Jun R., Englund, Erika E., Wang, Hang, Huang, Ruili, Huang, Pengxiang, Rastinejad, Fraydoon, Inglese, James, Austin, Christopher P., Johnson, Ronald L., Huang, Wenwei, Littman, Dan R.

Journal:

ACS Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 2.43 MB

english, 2013

28

Identification of small molecule compounds that inhibit the HIF-1 signaling pathway

Menghang Xia, Kun Bi, Ruili Huang, Ming-Hsuang Cho, Srilatha Sakamuru, Susanne C Miller, Hua Li, Yi Sun, John Printen, Christopher P Austin, James Inglese

Journal:

Molecular Cancer

Année:

2009

Langue:

english

Fichier:

PDF, 1.50 MB

english, 2009

29

Structure Mechanism Insights and the Role of Nitric Oxide Donation Guide the Development of Oxadiazole-2-Oxides as Therapeutic Agents against Schistosomiasis

Rai, Ganesha, Sayed, Ahmed A., Lea, Wendy A., Luecke, Hans F., Chakrapani, Harinath, Prast-Nielsen, Stefanie, Jadhav, Ajit, Leister, William, Shen, Min, Inglese, James, Austin, Christopher P., Keefer,

Journal:

Journal of Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 1.53 MB

english, 2009

30

A Robotic Platform for Quantitative High-Throughput Screening

Michael, Sam, Auld, Douglas, Klumpp, Carleen, Jadhav, Ajit, Zheng, Wei, Thorne, Natasha, Austin, Christopher P., Inglese, James, Simeonov, Anton

Journal:

Assay and Drug Development Technologies

Année:

2008

Langue:

english

Fichier:

PDF, 880 KB

english, 2008

31

A High-Throughput Screen for Aggregation-Based Inhibition in a Large Compound Library

Feng, Brian Y., Simeonov, Anton, Jadhav, Ajit, Babaoglu, Kerim, Inglese, James, Shoichet, Brian K., Austin, Christopher P.

Journal:

Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 252 KB

english, 2007

32

Rhodopsin Kinase: Expression in Baculovirus-Infected Insect Cells, and Characterization of Post-Translational Modifications

Kiweon Cha, Christophe Bruel, James Inglese and H. Gobind Khorana

Journal:

Proceedings of the National Academy of Sciences

Année:

1997

Langue:

english

Fichier:

PDF, 1.49 MB

english, 1997

33

Quantitative Analyses of Aggregation, Autofluorescence, and Reactivity Artifacts in a Screen for Inhibitors of a Thiol Protease

Jadhav, Ajit, Ferreira, Rafaela S., Klumpp, Carleen, Mott, Bryan T., Austin, Christopher P., Inglese, James, Thomas, Craig J., Maloney, David J., Shoichet, Brian K., Simeonov, Anton

Journal:

Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 3.24 MB

english, 2010

34

Identification of Small Molecule Modulators of Gene Transcription with Anticancer Activity

Tran, Tram Anh, Wichterman-Kouznetsova, Jennifer, Varghese, Diana, Huang, Ruili, Huang, Wenwei, Becker, Matthias, Austin, Christopher P., Inglese, James, Johnson, Ronald L., Martinez, Elisabeth D.

Journal:

ACS Chemical Biology

Année:

2014

Langue:

english

Fichier:

PDF, 651 KB

english, 2014

35

Comprehensive Mechanistic Analysis of Hits from High-Throughput and Docking Screens against β-Lactamase

Babaoglu, Kerim, Simeonov, Anton, Irwin, John J., Nelson, Michael E., Feng, Brian, Thomas, Craig J., Cancian, Laura, Costi, M. Paola, Maltby, David A., Jadhav, Ajit, Inglese, James, Austin, Christophe

Journal:

Journal of Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 1.42 MB

english, 2008

36

A quantitative high-throughput screen for modulators of IL-6 signaling: a model for interrogating biological networks using chemical libraries

Johnson, Ronald L., Huang, Ruili, Jadhav, Ajit, Southall, Noel, Wichterman, Jennifer, MacArthur, Ryan, Xia, Menghang, Bi, Kun, Printen, John, Austin, Christopher P., Inglese, James

Journal:

Molecular BioSystems

Année:

2009

Langue:

english

Fichier:

PDF, 2.44 MB

english, 2009

37

Relationship between imaging and blood-based transcription profiles in primary-progressive multiple sclerosis

Inglese, Matilde, Gerald, Christophe, Teodorescu, Roxana, Farrell, Colleen, Fabian, Michelle, Lublin, Fred

Journal:

Journal of Neuroimmunology

Année:

2014

Langue:

english

Fichier:

PDF, 49 KB

english, 2014

38

The synthesis and evaluation of dihydroquinazolin-4-ones and quinazolin-4-ones as thyroid stimulating hormone receptor agonists

Englund, Erika E., Neumann, Susanne, Eliseeva, Elena, McCoy, Joshua G., Titus, Steven, Zheng, Wei, Southall, Noel, Shinn, Paul, Leister, William, Thomas, Craig J., Inglese, James, Austin, Christopher

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 132 KB

english, 2011

39

A Multiplex Calcium Assay for Identification of GPCR Agonists and Antagonists

Liu, Ke, Southall, Noel, Titus, Steve A., Inglese, James, Eskay, Robert L., Shinn, Paul, Austin, Christopher P., Heilig, Markus A., Zheng, Wei

Journal:

Assay and Drug Development Technologies

Année:

2010

Langue:

english

Fichier:

PDF, 2.83 MB

english, 2010

40

A Cell-Based Assay for I κ B α Stabilization Using A Two-Color Dual Luciferase-Based Sensor

Davis, R. Eric, Zhang, Ya-Qin, Southall, Noel, Staudt, Louis M., Austin, Christopher P., Inglese, James, Auld, Douglas S.

Journal:

Assay and Drug Development Technologies

Année:

2007

Langue:

english

Fichier:

PDF, 5.26 MB

english, 2007

41

Evaluation of Micro-Parallel Liquid Chromatography as a Method for HTS-Coupled Actives Verification

Simeonov, Anton, Yasgar, Adam, Klumpp, Carleen, Zheng, Wei, Shafqat, Naeem, Oppermann, Udo, Austin, Christopher P., Inglese, James

Journal:

Assay and Drug Development Technologies

Année:

2007

Langue:

english

Fichier:

PDF, 189 KB

english, 2007

42

A 1,536-Well-Based Kinetic HTS Assay for Inhibitors of Schistosoma mansoni Thioredoxin Glutathione Reductase

Lea, Wendy A., Jadhav, Ajit, Rai, Ganesha, Sayed, Ahmed A., Cass, Cynthia L., Inglese, James, Williams, David L., Austin, Christopher P., Simeonov, Anton

Journal:

Assay and Drug Development Technologies

Année:

2008

Langue:

english

Fichier:

PDF, 175 KB

english, 2008

43

Assay, Preclinical, and Clinical Brick Walls and Opportunities for System Change Through GRANDRx

Terry, Sharon, Austin, Christopher, Inglese, James, Meeker, David, Terry, Patrick

Journal:

Assay and Drug Development Technologies

Année:

2010

Langue:

english

Fichier:

PDF, 468 KB

english, 2010

44

Compound Cytotoxicity Profiling Using Quantitative High-Throughput Screening

Menghang Xia, Ruili Huang, Kristine L. Witt, Noel Southall, Jennifer Fostel, Ming-Hsuang Cho, Ajit Jadhav, Cynthia S. Smith, James Inglese, Christopher J. Portier, Raymond R. Tice and Christopher P. A

Journal:

Environmental Health Perspectives

Année:

2008

Langue:

english

Fichier:

PDF, 3.49 MB

english, 2008

45

Optimization and Validation of Two Miniaturized Glucocerebrosidase Enzyme Assays for High Throughput Screening

Urban, Daniel, Zheng, Wei, Goker-Alpan, Ozlem, Jadhav, Ajit, LaMarca, Mary, Inglese, James, Sidransky, Ellen, Austin, Christopher

Journal:

Combinatorial Chemistry & High Throughput Screening

Année:

2008

Langue:

english

Fichier:

PDF, 401 KB

english, 2008

46

A Miniaturized Glucocorticoid Receptor Translocation Assay Using Enzymatic Fragment Complementation Evaluated with qHTS

Zhu, Ping, Zheng, Wei, Auld, Douglas, Jadhav, Ajit, MacArthur, Ryan, Olson, Keith, Peng, Kun, Dotimas, Hyna, Austin, Christopher, Inglese, James

Journal:

Combinatorial Chemistry & High Throughput Screening

Année:

2008

Langue:

english

Fichier:

PDF, 714 KB

english, 2008

47

A High Throughput Fluorescence Polarization Assay for Inhibitors of the GoLoco Motif/G-alpha Interaction

Kimple, Adam, Yasgar, Adam, Hughes, Mark, Jadhav, Ajit, Willard, Francis, Muller, Robin, Austin, Christopher, Inglese, James, Ibeanu, Gordon, Siderovski, David, Simeonov, Anton

Journal:

Combinatorial Chemistry & High Throughput Screening

Année:

2008

Langue:

english

Fichier:

PDF, 839 KB

english, 2008

48

Insular Epilepsy: Clinical, Electrophysiological Features, and Surgical Treatment

Marashly, Ahmad, Lew, Sean, Inglese, Christopher, Mueller, Wade

Journal:

Journal of Pediatric Epilepsy

Année:

2017

Langue:

english

Fichier:

PDF, 292 KB

english, 2017

49

Quantitative High-Throughput Screen Identifies Inhibitors of the Schistosoma mansoni Redox Cascade

Simeonov, Anton, Jadhav, Ajit, Sayed, Ahmed A., Wang, Yuhong, Nelson, Michael E., Thomas, Craig J., Inglese, James, Williams, David L., Austin, Christopher P., Jones, Malcolm

Journal:

PLoS Neglected Tropical Diseases

Année:

2008

Langue:

english

Fichier:

PDF, 360 KB

english, 2008

50

Compound Cytotoxicity Profiling Using Quantitative High-Throughput Screening

Xia, Menghang, Huang, Ruili, Witt, Kristine L., Southall, Noel, Fostel, Jennifer, Cho, Ming-Hsuang, Jadhav, Ajit, Smith, Cynthia S., Inglese, James, Portier, Christopher J., Tice, Raymond R., Austin,

Journal:

Environmental Health Perspectives

Année:

2007

Langue:

english

Fichier:

PDF, 335 KB

english, 2007